| Effect of yohimbine and 4-aminopyridine on gastroduodenal transit time in xylazine-pentobarbital-anesthetized dogs |
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Dong-jun Kim, Min-chul Choi, Jai-ki Sung |
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College of Veterinary Medicine, Seoul National University |
| Xylazine과 pentobarbital로 마취한 개에서 yohimbine과 4-aminopyridine투여가 위십이지장 통과 시간에 미치는 영향 |
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김동준, 최민철, 성재기 |
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서울대학교 수의과대학 |
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| Abstract |
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The present study was undertaken to determine the effect of xylazine-pentobarbital anesthesia on the gastroduodenal transit time of barium sulfate and whether this condition can be antagonized by yohimbine, 4-aminopyridine and yohimbine+4-aminopyridine in dogs. Xylazine-pentobarbital anesthesia prolonged the gastroduodenal transit time to $121.50{pm}21.25$ minutes compared with $5.25{pm}0.90$ minutes of control. Yohimbine and yohimbine+4-aminopyridine reversed $121.50{pm}21.25$ minutes of transit time of anesthetized dog to $25.25{pm}6.83$ and $63.25{pm}15.69$ minutes, respectively. 4-aminopyridine alone, $115.75{pm}$18.35 minutes, was not effective in reversing the xylazine-pentobarbital-induced prolongation of gastroduodenal transit time. Yohimbine was the most effective for reversal of xylazine-pentobarbital-induced prolongation of gastroduodenal transit time in dogs. |
| Key Words:
gastroduodenal transit time, xylazine, pentobarbital, yohimbine, 4-aminopyridine |
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