| The effects of lead poisoning on the accumulation of lead, zinc, copper, iron and calcium in tissues of rats |
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Oh-deog Kwon1, Joo-mook Lee1, Seung-ok Lee1, Jin-ho Park1, Hyun-beom Lee2, Jong-sik Jang2, Joon-seok Chae3 |
1College of Veterinary Medicine, Chobuk National University
2College of Veterinary Medicine, Kyungpook National University
3Department of Veterinary Pathobiology, Texas A&M University |
| Rat에 있어서 실험적 납중독이 체조직내 납 및 무기질함량에 미치는 영향 |
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권오덕1, 이주묵1, 이승옥1, 박진호1, 이현범2, 장종식2, 채준석3 |
1전북대학교 수의과대학
2경북대학교 수의과대학
3텍사스 A&M대학교 수의과대학 |
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| Abstract |
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This experiment was carried out to clarify the effect of lead poisoning on the lead and essential trace elements homeostasis of tissues in rats. Fifty female Wistar rats, 7 weeks old, were divided into four experimental groups(B, C, D, and E) and a control(A). The four experimental groups received diets contaminated artificially with 10 (B group), 100 (C group), 1,000 (D group) and 5,000 (E group) ${mu}g/g$ of lead as lead acetate, respectively. The control group received normal diet. Rats were necropsied on the 4th or 8th week of experimental periods and heart, liver, spleen, kidney, muscle, lung and hair were taken. The tissues were analysed for lead, copper, zinc, iron and calcium content by atomic absorption spectrophotometry. From these experiments following results ware obtained ; In C group, lead content of the heart, liver, kidney and hair were significantly increased both on the 4th and 8th week of experiment. In D and E group, lead content of all tissues including heart, liver, spleen, kidney, muscle, hair and lung were significantly increased in accordance with the lead contamination both on the 4th and 8th week of experiment. In C group, copper content of tissues were significantly increased in the heart, liver, kidney and lung on the 4th week and all tissues on the 8th week of experimental periods. In D and E group, copper content of the liver were significantly increased both on the 4th and 8th week of experiment. But the copper content of tissues were gradually decreased compared with C group in accordance with the lead contamination. Especially the content in spleen, heart or kidney were significantly decreased compared with the control group. The zinc content of kidney, heart, or spleen were decreased in D and E groups whereas the iron and calcium content showed no significant change. |
| Key Words:
rat, lead poisoning, copper, zinc, iron |
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