| Time relationship between the change of blood glucose concentration and the change of hemoglobin A1 concentration in experimentally induced diabetic dogs |
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Chang-woo Lee, Bonn-won Kim |
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College of Veterinary Medicine, Seoul National University |
| 실험적으로 당뇨병을 유발시킨 개에 있어서 혈당량과 Hemoglobin A1 농도의 변화의 시간적인 상관관계 |
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이창우, 김본원 |
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서울대학교 수의과대학 |
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| Abstract |
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Fifteen mongrel dogs (14 male and 1 female) were injected intravenously with 30mg of streptozotocin and 50mg of alloxan monohydrate per kilogram of body weight to induce diabetes mellitus. Before treatment with streptozotocin and alloxan fasting serum glucose concentration was determined every other day or thrice a week (Monday, Wednesday, Friday) for 3 months. Among 15 dogs 4 dogs developed diabetes mellitus and survived more than 9 weeks without injection of insulin. After treatment fasting serum glucose and hemoglobin $A_1$ concentrations of the 4 dogs were determined every other day or thrice a week. Fasting serum glucose concentration increased acutely from 24 hours after treatment and then showed severe fluctuation. Hemoglobin $A_1$ concentration increased gradually until 7~9 weeks after treatment and then showed very slow increase afterwards. Correlation of hemoglobin $A_1$ to fasting glucose concentration was relatively weak(r = 0.10~0.80). Hemoglobin $A_1$ and fasting glucose concentration of preceding 7 week showed very high correlation (r = 0.98~0.99). It was indicated that hemoglobin $A_1$ concentration in chemically induced diabetic dogs reflects mean glucose concentration of preceding 7~9 weeks. |
| Key Words:
diabetes mellitus, hemoglobin $A_1$, streptozotocin, alloxan |
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