| The Distribution of TrkA in the Olfactory Bulb and Basal Nucleus of the Mongolian Gerbil after Birth |
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Xilin Hou1, Il-kwon Park1, Kyung-youl Lee1, Mi-sun Park1, Sang-keun Kim1, Kang-yi Lee2, Geun-jwa Lee3, Moo-kang Kim1 |
1College of Veterinary Medicine, Chungnam National University
2College of Oriental Medicine, Daejeon University
3Chungnam Livestock & Veterinary Service Institute |
| 출생 후 몽골리안 저빌의 후각망울과 기저핵에서 TrkA의 분포 |
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후시린1, 박일권1, 이경열1, 박미선1, 김상근1, 이강이2, 이근좌3, 김무강1 |
1충남대학교 수의과대학
2대전대학교 한의과대학
3충남축산위생연구소 |
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| Abstract |
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TrkA is an essential component of the high affinity NGF receptor necessary to the mediate biological effects of the neurotrophins NGF. Here we report on the expression of TrkA in the olfactory bulb and basal nucleus of Mongolian gerbil brain during the postnatal development. The expressions of TrkA were identified in a immunohistochemical method. Higher levels of TrkA immunoreactivity were detected in septum than that in olfactory bulb and caudate putamen (CPu). But TrkA was not observed before postnatal days (PND6) in olfactory bulb and PND9 in CPu. No TrkA-positive cell was detectable in the olfactory fiber layer. Several regions, such as olfactory bulb and CPu, showed weak labeling. These data show that expression of TrkA is developmentally regulated during postnatal Mongolian gerbil brain development and suggest that high affinity neurotrophinreceptors mediate a transient response to neurotrophins in many regions during the brain ontogeny. |
| Key Words:
TrkA, Mongolian gerbil, olfactory bulb, basal nucleus, immunohistochemistry |
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