| Effects of caffeine on capsular fibrous proliferation induced by N-bis(2-hydroxypropyl)nitrosamine and sulfadimethoxine in the thyroid glands |
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Hwa-young Son1, Won-kee Yoon2, Young-heun Jee3, Si-yoon Ryu1, Jung-ran Kim4, Sung-whan Cho1 |
1College of Veterinary Medicine, Chungnam National University
2Korea Research Institute of Bioscience and Biotechnology
3Department of Veterinary Medicine, Cheju National University
4Statistical Training Center, National Institute of Professional Administration |
| Caffeine이 N-bis(2-hydroxypropyl)nitrosamine과 sulfadimethoxine에 의해 유발된 갑상선 피막의 섬유성 증식에 미치는 영향 |
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손화영1, 윤원기2, 지영흔3, 류시윤1, 김정란4, 조성환1 |
1충남대학교 수의과대학
2한국생명공학연구원
3제주대학교 수의학과
4국가전문행정연수원 통계연수원 |
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| Abstract |
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Caffeine (1,3,7-trimethylxanthine), a central nervous system stimulant, is contained in various foods, beverages and over-the-counter medications. Sulfadimethoxine (SDM) is one of the anti-thyroid agents and induces proliferation of thyroid capsule in two stage thyroid carcinogenesis model using N-bis(2-hydroxypropyl)nitrosamine (DHPN). In this study, we examined the effect of caffeine on fibrous proliferation of thyroid capsule in DHPN and SDM-treated rats. Five-week-old male F344 rats were given a single subcutaneous injection of DHPN (2,800 mg/kg, body weight). Starting one week thereafter, SDM (1,000 ppm in drinking water) with or without caffeine (1,500 ppm in diet) was administered for 12 weeks. All animals were autopsied and histopathological examination of the thyroid glands was performed. Thyroid follicular proliferative changes were induced in all rats treated with DHPN+SDM. In addition, the proliferation of perithyroidal fibrous tissue and pleomorphic thyroid follicular cells within the capsule were observed in DHPN+SDM treated group. Caffeine would not be related to these lesions in this experimental condition. although pentoxifylline, a methyl xanthine derivative, has an anti fibrotic effects. |
| Key Words:
caffeine, sulfadimethoxine, capsular fibrosis, histopathology |
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