| Toxicity study of GC-100X in rats and beagles |
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Kyung-Sun Kang, Sung-Dae Cho, Nam-Shik Ahn, Ji-Won Jung, Se-Ran Yang, Joon-Suk Park, Ki-Soo Park, In-Sun Hong, Min-Soo Seo, Eun-Hye Jo, Ba Tiep Nguyen, Yong-Soon Lee |
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Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University |
| 랫드와 비글에서 GC-100X 세정제의 독성에 대한 연구 |
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강경선, 조성대, 안남식, 정지원, 양세란, 박준석, 박기수, 홍인선, 서민수, 조은혜, , 이영순 |
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서울대학교 수의대학교 공중보건학교실 |
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| Abstract |
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Because cleaning products are part of our everyday lives, it is essential that they should not present significant risks to health. However, many petrochemicals in most soaps and detergents can be absorbed through the scalp and skin and, over time, accumulate in the organs and tissues. This accumulation may result in brain, nerve, and liver damage. Therefore, it is interested in developing non-harmful detergent. According to Korea Research Institute of Chemical Technology, GC-100X may be non-harmful and non-corrosive alkaline ionic water (pH 12). It is composed of hydroxyl radicals and supplemented with xylitol. To evaluate influence of GC-100X on rats and beagles, GC-100X was diluted with distilled water (25%, 50%, and 100% solution respectively). Each of diluted GC-100X was daily treated per oral. In body weight analysis, urinary analysis, ophthalmological test and autopsy, we did not find any significance, but in serum biochemical analysis and hematological analysis, we found some significances in middle dose group compared with control group. These significances in serum biochemical analysis and hematological analysis may be not induced by GC-100X, because it was not found to be significant from control group in histopathological examination. Thus, it is concluded that NOEL(No Observed Effect Level) of GC-100X may be higher than all treatment doses used in this study, and GC-100X may be a non-toxic detergent. |
| Key Words:
GC-100X, non-toxic detergent, petrochemicals, NOEL(No Observed Effect Level) |
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