| Morphological evaluation on the effect of panaxadiol series ginsenosides in irradiated mice |
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Hae-june Lee, Se-ra Kim, Sung-ho Kim |
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College of Veterinary Medicine, Chonnam National University |
| 방사선 조사 마우스에서 인삼 panaxadiol계 ginsenosides의 효과에 관한 형태학적 평가 |
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이해준, 김세라, 김성호 |
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전남대학교 수의과대학 |
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| Abstract |
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The purpose of the study was to investigate the effect of ginseng saponins (panaxadiol, ginsenoside $Rb_1$, $Rb_2$, Rc, Rd) on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with gamma-ray. ICR mice were given each saponin (i.p. 50 mg/kg of body weight) at 24 hours before irradiation. The radioprotective effects of saponins were compared with the irradiation control respectively. The jejunal crypts were protected by pretreatment with ginsenoside Rc (p<0.05) and Rd (p<0.05). The spleen colony was increased by pretreatment with panaxadiol (p<0.05) and ginsenoside Rd (p<0.05). And the frequency of radiation induced apoptosis was significantly reduced by pretreatment with panaxadiol (p<0.05), ginsenoside Rb2 (p<0.05), Rc (p<0.05) and Rd (p<0.01). These results suggest that ginsenoside Rc, Rd might have a major radioprotective effect. |
| Key Words:
saponin, jejunal crypt, spleen colony, apoptosis, radiation |
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