| Incidence of micronuclei in lymphocytes of pig in the high background radiation area (Cheongwon-gun and Boeun-gun) |
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Hae-June Lee1, Chang-Mo Kang2, Se-Ra Kim1, Jin-Hee Lee1, Joong-Sun Kim1, Jong-Choon Kim1, Ill-Hwa Kim3, Tae-Hwan Kim4, Si-Yun Ryu5, Sung-Kee Jo6, Soo-Yong Choi2, Sung-Ho Kim1 |
1College of Veterinary Medicine, Chonnam National University
2Korea Institute of Radiological & Medical Science
3College of Veterinary Medicine, Chungbuk National University
4College of Veterinary Medicine, kyungbuk National University
5College of Veterinary Medicine, Chungnam National University
6Food Irradiation Team, Korea Atomic Energy Research Institute |
| 국내 자연 방사선 고준위 지역(청원군, 보은군) 사육 돼지의 림프구 미소핵 발생 평가 |
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이해준1, 김창모2, 김세라1, 이진희1, 김중선1, 김종춘1, 김일화3, 김태환4, 류시윤5, 조성기6, 최수용2, 김성호1 |
1전남대학교 수의과대학
2원자력의학원
3충북대학교 수의과대학
4경북대학교 수의과대학
5충남대학교 수의과대학
6한국원자력연구소 방사선이용연구부 |
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| Abstract |
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Cytogenetic and hematological analysis was performed in peripheral blood obtained from pigs bred in the high background radiation areas (HBRA) (Cheongwon-gun and Boeun-gun) and a control area. The frequencies of gamma-ray induced micronuclei (MN) in the cytokinesis-blocked (CB) lymphocytes at several doses were measured in three pigs. An estimated dose of radiation was calculated by a best fitting linear-quadratic model based on the radiation-induced MN formation from the swine lymphocytes exposed in vitro to radiation over the range from 0 mGy to 1,969 mGy. The measurements performed after irradiation showed dose-related increases in the MN frequency in each donors. The results were analyzed using a linear-quadratic model with a line of best fit of $y=0.0005404D^2+0.04237D+0.00833$ [y = number of MN/cytokinesis-blocked (CB) cells and D = irradiation dose in Gy]. MN rates per 1,000 CB lymphocytes of pig from the HBRA (Cheongwon-gun, Boeun-gun) and the control area were $6.70{pm}2.36$, $9.00{pm}3.50$ and $11.00{pm}2.98$, respectively. The MN frequencies of CB lymphocytes from pigs bred in three areas means that the values are within the background variation in this experiment. The MN frequencies and hematological values were similar regardless of whether the pigs were bred in the HBRA or the control area. |
| Key Words:
high background radiation area, lymphocyte, micronuclei, pig |
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