| Anti-inflammatory activities of a herbal preparation (HemoHIM) in colitis induced by trinitrobenzene sulfonic acid in rats |
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Hae-June Lee1, Se-Ra Kim1, Chang-Jong Moon1, Jong-Choon Kim1, Chun-Sik Bae1, Seong-Soo Kang1, U-Hee Jung2, Hae-Ran Park2, Sung-Kee Jo2, Sung-Ho Kim1 |
1College of Veterinary Medicine, Chonnam National University
2Advanced Radiation Technology Institute, KAERI |
| Trinitrobenzene sulfonic acid에 의해 유발된 랫드의 대장염에서 HemoHIM의 항염증 효과 |
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이해준1, 김세라1, 문창종1, 김종춘1, 배춘식1, 강성수1, 정우희2, 박혜란2, 조성기2, 김성호1 |
1전남대학교 수의과대학
2한국원자력연구소 |
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| Abstract |
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The cause and pathogenesis of inflammatory bowel disease remain unknown and no definitetherapy exists until now. The present study was conducted to investigate the anti-inflammatory effectsof a herbal preparation (HemoHIM) in colitis induced by 30 mg of trinitrobenzene sulfonic acid (TNBS)in rats. Sprague-Dawley rats were divided into 5 groups. Each group was treated with 1 mg ofHemoHIM/ml of drinking water, 4 mg of HemoHIM/ml of drinking water, 50 mg of HemoHIM/kgof body weight (i.p. once every other day) or 10 mg/kg of HemoHIMof body weight (i.p. onceevery other day) from the next day. After 2 weeks, rats were sacrificed and morphologic featuresof colons were examined. Ulceration, adhesion, thickening and dilatation were noticed in the colonicmucosa after TNBS instillation. Intraperitoneal injection of HemoHIM (50 and 100 mg/kg of bodyweight) showed the anti-inflammatory effect on adhesion, thickening, dilatation, ulceration, and theinhibition effect on damage score by 72.7% and 90.9%, respectively. Histologically, the colon of TNBS-treated rat showed inflammatory cell infiltration by polymorphonuclear cells, multiple erosive lesionsignificant improvement in these symptoms. The results obtained suggest marked anti-inflamatoryactivity of the HemoHIM at the dose levels examined. |
| Key Words:
anti-inflammatory, colitis, HemoHIM, TNBS |
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