| Elder ages decreases the susceptibility for Helicobacter pylori infection in an animal model |
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Jin-Uk Lee1, Seung-Hee Kim1, Tan-Woo Park2, Okjin Kim2 |
1College of Medicine, Seoul National University
2College of Life Science and Natural Resources, Wonkwang University |
| Helicobacter pylori의 감수성과 숙주 연령과의 상관성 연구 |
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이진욱1, 김승희1, 박탄우2, 김옥진2 |
1서울대학교 의과대학 실험동물학교실
2원광대학교 생명자원과학대학 동물질병연구실 |
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| Abstract |
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Helicobacter pylori (H. pylori) is an important bacterial pathogen that causes chronic gastritisand is associated with gastroduodenal ulcer disease, adenocarcinoma of the distal stomach, and gastricH. pylori infection associated with host agehave not been well-defined in human. To evaluate the difference in host susceptibility to infection in relationto age of acquisition of H. pylori infection, we designed an experiment involving inoculation of H. pyloriATC 43504 at different ages of Mongolian gerbils. H. pylori was inoculated at 5 weeks and 18 monthsof age, as representatives of early and late infection, respectively. Animals were sacrificed 1 week and 4weeks after challenge, and the stomach was removed from each animal for bacterial culture, histologicalexamination, and polymerase chain reaction test. 5 week-old gerbils revealed infection andmaintained continuously its infection until 4 weeks. However, old gerbils did not maintained H. pyloriinfection. These data suggest the insusceptibility of H. pylori in old Mongolian gerbils and the importanceof animal ages for successful animal experimental infection. Also, the results demonstrated that earlyinfection of H. pylori increases its host susceptibility, as compared to the case with later infection, possiblybecause of differences in host gastric mucosal factors and imunologic responses. |
| Key Words:
age, Helicobacter pylori, Mongolian gerbil, susceptibility |
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