Multicentric T cell lymphoma in a Maltese dog |
Ji-Youl Jung1, Sang-Chul Kang1, In-Soon Roh2, Hyun-Joo Sohn2, Young-Min Yun1, Jung-Hun Kim1, Kyoung-Kap Lee1, Min-Chan An3, Jong-Hee Bae1, Jae-Hoon Kim1 |
1Department of Veterinary Medicine, Cheju National University 2National Veterinary Research & Quarantine Service 3Halla Pet Hospital |
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Abstract |
A case of multicentric high grade T cell lymphoma is reported in a 5-year-old male Maltese dog with generalized lymphadenopathy. The dog showed depression, anorexia, blindness, jaundice, arrhythmia, and hematuria for 8 months. Complete blood count and chemistry profile revealed anemia and increased alanine transferase, alkaline phosphatase, total bilirubin, and total cholesterol. Grossly, most of lymph nodes, spleen, and liver were enlarged and neoplastic masses were occupied in these tissues. Histologically, massive accumulation of small noncleaved neoplastic lymphocytes with high mitotic figures was observed in all lymph nodes and spleen. Infiltration of neoplastic lymphocytes was also noted in the lung, liver, kidney, eye, skin, muscle, and bone marrow of femur. Immunohistochemistry revealed that tumor cells were CD3-positive and but CD79a-negative, consistent with T-cell lineage. In our best knowledge, this is the first report of multicentric lymphoma clarified the origin of tumor cells in Korea. |
Key Words:
CD3, dog, immunohistochemistry, multicentric lymphoma, T -cell |
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