Effect of chicken egg yolk antibody on canine parvoviral enteritis in pups

Oh, Kyung-Eun; Jeoung, Seok-Young; Kim, Bo-Mi; Jang, Sang-Ho; Lee, Nam-Hyung; Cho, Youngjae; Kim, Doo; Choi, Jung Hoon; Hahn, Tae-Wook

doi:2014.54.2.67

Korean J Vet Res > Volume 54(2); 2014 > Article

Original Article

Korean Journal of Veterinary Research 2014;54(2):67-73.
DOI: https://doi.org/10.14405/kjvr.2014.54.2.67 Published online June 30, 2014.

Effect of chicken egg yolk antibody on canine parvoviral enteritis in pups

Kyung-Eun Oh¹, Seok-Young Jeoung², Bo-Mi Kim³, Sang-Ho Jang³, Nam-Hyung Lee³, Youngjae Cho¹, Doo Kim¹, Jung Hoon Choi¹, Tae-Wook Hahn¹

¹College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University
²Gangnam Animal Clinics
³ADBIOTECH Co., Ltd.

개 파보바이러스성 장염에 대한 난황항체의 예방 및 치료 효과

오경은¹, 정석영², 김보미³, 장상호³, 이남형³, 조영재¹, 김두¹, 최정훈¹, 한태욱¹

¹강원대학교 수의과대학 및 동물의학종합연구소
²강남동물병원
³(주)애드바이오텍

Abstract

Preventive and therapeutic effects of egg yolk antibody, immunoglobulin Y (IgY), against canine parvovirus (CPV) was evaluated in 25 pups orally challenged with CPV-2a. Oral administration of IgY using powder, paste and coated paste delivery systems was compared. Each type of IgY was administered orally for 17 days from 3 days before challenge. The group of pups administered coated IgY showed mild symptoms such as a moderate decrease in total white blood cell count, no depression, vomiting and diarrhea when compared with other groups. The overall clinical score of the group of pups administered coated IgY was significantly lower than that of the challenge control group. However, mortality did not differ among groups because not all pups received symptomatic treatment. These results implied that oral treatment of coated IgY could improve therapeutic effects against CPV challenge if pups received symptomatic treatment.

Key Words: canine parvoviral enteritis, egg yolk antibody, immunotherapy, oral administration