| Alopecia areata in a spayed pug: clinical and immunohistochemical findings |
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Seul-Gy Park1, Chang-Min Lee1, Jae-Ik Han2, Seung-Gon Kim1, Ha-Jung Kim1, Hee-Myung Park1 |
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University
2Department of Veterinary Wild Animal Medicine, College of Veterinary Medicine, Chonbuk National University |
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| Abstract |
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A two-year-old spayed female pug presented with symmetrical hyperpigmented alopecic lesions on her axillary and inguinal regions. There were no remarkable findings in dermatologic examinations and hormonal assays. Histological examination of biopsied tissues revealed prominent lymphocytic perifolliculitis along with shrunk hair follicles. Immunohistochemistry for CD3, CD79a, CD4, and CD8 showed a positive stain for CD4 antigen around hair bulbs, suggesting CD4 positive T lymphocyte infiltration. This case suggests the possibility that CD4 T lymphocyte-mediated inflammatory reaction could be a main mechanism in canine alopecia areata. Additional studies are warranted to investigate the immunological mechanism in canine species. |
| Key Words:
alopecia areata, autoimmune disease, T lymphocyte |
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