Studies on Gentamicin-induced Nephrotoxicity in Rats

Cho, In-soo; Kim, Tae-jong; Yoon, Hwa-joong

Korean Journal of Veterinary Research 1986;26(1):125-137.

In-soo Cho, Tae-jong Kim, Hwa-joong Yoon

Department of Veterinary Medicine, College of Animal Husbandry, Kon Kuk University

랫트에서의 Gentamicin신장독성(腎臟毒性)에 관한 연구(硏究)

조인수, 김태종, 윤화중

건국대학교 축산대학 수의학과

Abstract

Sprague-Dawley rats received subcutaneous injections of gentamicin sulfate, 50 and 100mg/kg for 3, 7 and 10 days. The hematological and blood chemical values were determined. Kidneys were examined histologically and ultrastructurally. The results obtained were summarized as follows; 1. The serum values of aspartate transaminase, blood urea nitrogen and creatinine in the rats administered gentamicin, 50 and 100mg/kg/day were significantly increased than those in the control. 2. The ratio of kidney weight to body weight was significantly increased in the rats injected gentamicin, 100mg/kg for 10 days than those in the control. 3. The brush borders of proximal convoluted tubules in the kindneys received gentamicin, 50 and 100mg/kg/day were decreased or absent in periodic acid-Schiff staining. 4. The necrosis of proximal convoluted tubules was shown in the rats given gentamicin, 50 and 100mg/kg for 7 and 10 days. 5. The regeneration of the proximal tubular epithelia was observed in the rats treated gentamicin, 100mg/kg for 10 days. 6. The number and size of lysosomes were increased in the proximal convoluted tubules of the rats injected gentamicin, 50mg/kg for 7 days, many of which contained myeloid bodies.