Korean Journal of Veterinary Research 1987;27(1):35-40.
Bronchodilator Effect of Higenamine in Isolated Guinea-pig Tracheal Smooth Muscle
Hyo-in Yun1, Ki-chorl Chang1, Seong-geun Hong1, Chang-eop Lee2
1College of Medicine, Gyeonsang National University
2College of Veterinary Medicine, Seoul National University
Higenamine의 Guinea pig 기관 평활근 이완작용
윤효인1, 장기철1, 홍성근1, 이창업2
1경상대학교 의과대학
2서울대학교 수의과대학
Abstract
Higenamine, a benzyltetrahydroisopuinoline analog isolated from aconite tuber, has potent isotropic action. Recent studies suggest it may have beta receptor agonistic property in that its inotropic action is blocked by propranolol in isolated rabbit heart. However, no study has been carried out on other organs than heart. Higenamine is expected to have pharmacological actions on smooth muscle on the ground that it has catecholamine moiety and tetrahydrosioquinoline nucleus in its chemical structure, both of which are well known to have smooth muscle relaxation effects. Therefore present study was aimed at determining whether higenamine has bronchodilating effect in isolated guinea pig trachea smooth muscle rich in adrenergic beta receptor and if any, it has agonistic effect on beta receptor. The results were summarized as follows : 1. Higenamine had remarkable bronchodilating effect in guinea pig tracheal smooth muscle in a dose-dependent manner. 2. Bronchodilator effect of higenamine in isolated guinea pig tracheal smooth muscle was blocked competitively by propranolol. The $pD_2$ value of higenamine in isolated guinea pig tracheal smooth muscle was 5.65 and the $pA_2$ value of propranolol against higenamine in the same preparation was 7.97.


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