Changes in the serum immunoglobulin levels and viral antibody titers of colostrum-conferred Korean native calves during the first 12 weeks postpartum

Kim, Doo; Han, Hong-ryul

Korean Journal of Veterinary Research 1989;29(2):83-90.

Doo Kim, Hong-ryul Han

College of Veterinary Medicine, Seoul National University

초유를 섭취한 한우 송아지의 출생후 12주 동안의 혈청 면역글로불린과 각종 바이러스 항체가의 변화

김두, 한홍율

서울대학교 수의과대학

Abstract

The changes in serum total protein and immunoglobulin levels, and BVD, IBR and PI-3 viral neutralizing antibody titers in colostrum-conferred Korean native calves during the first 12 weeks postpartum were studied, and the results obtained were summerized as follows: The Mean concentration of total protein, total immunoglobulin, IgG, IgM and IgA in sera of 9 calves at birth were $3.8{pm}0.5g/dl$, $0.27{pm}0.15mg/ml$, $0.06{pm}0.08mg/ml$, $0.21{pm}0.11mg/ml$, and extremely low concentration, respectively. Serum total protein level reached a maximum at 20 hours after birth, total immunoglobulin, IgG, and IgM levels at 24 hours, and IgA level at 28 hours, respectively. Serum IgA level reached a minimum at 4 weeks old, IgM level at 5 weeks, total immunoglobulin level at 8 weeks, and IgG level at 10 weeks, respectively. After then those levels had begun to increase, but total protein level was still decreasing at 12 weeks old. The half-lives of IgG, IgM, and IgA were 21.1 days, 4.0 days, and 2.6 days-respectively. In 10 Korean native cows immediately after parturition, serum neutralizing antibody titers specific to BVD, IBR and PI-3 virus were $8.7{pm}1.5{log}_2$, $5.7{pm}1.2{log}_2$, and $6.8{pm}1.01{log}_2$, respectively. And colostral neutralizing antibody titers against BVD, IBR, and PI-3 virus were $10.1{pm}1.4{log}_2$, $6.8{pm}1.3{log}_2$ and $7.8{pm}1.7{log}_2$, respectively. Before suckling the colostrum, SN antibody titers against BVD, IBR, and PI-3 virus were undetectable from all of 9 Korean native calves. Nevertheless SN antibody titer against BVD virus reached a maximum level ($9.2{pm}0.6{log}_2$) at 24 hours after birth, that against IBR virus ($6.1{pm}1.0{log}_2$) at 20 hours after birth, and that against PI-3 virus ($6.8{pm}0.9{log}_2$) at 32 hours after birth, respectively. In 12 weeks old calves, the SN antibodies against BVD and IBR virus were still decreasing, but that against PI-3 virus reached a minimum at 10 weeks, and increased after 12 weeks of age. The half-lives of SN antibodies against BVD, PI-3 and IBR, virus were 16.0 days, 22.6 days, and 25.5 days, respectively.

Key Words: Korean native calf, immunoglobulins, passive immunity, viral antibody titer