Korean Journal of Veterinary Research 1990;30(3):283-286.
Effect of nifedipine against carrageenan-induced paw oedema in rats
Dong-ho Shin
College of Veterinary Medicine, Chonnam National University
흰쥐에서 carrageenan에 의한 족부종(足浮腫)에 대한 nifedipine의 영향
신동호
전남대학교 수의과대학
Abstract
The effects of nifedipne and verapamil were compared on carrageenan-induced paw edema in rats and the results are summarized as follows: Carrageenan induced severe acute paw edema within 30 minutes and the maximum effect was achieved around 4 hours after administration. The carrageenan-induced paw edema was prominantly reduced by pretreatments of indomethacin (2mg/kg, p.o.) and nifedipine (10 and 20mg/kg, i.p.), whereas verapamil had no effect on the carrageenan-induced paw edema. These results suggest that calcium antagonists, nifedipine and verapamil, have a different effect on the inflammatory response induced by carrageenan.
Key Words: carrageenan, nifedipine, rat paw oedema, calcium antagonist


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