| Effect of nifedipine against carrageenan-induced paw oedema in rats |
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Dong-ho Shin |
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College of Veterinary Medicine, Chonnam National University |
| 흰쥐에서 carrageenan에 의한 족부종(足浮腫)에 대한 nifedipine의 영향 |
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신동호 |
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전남대학교 수의과대학 |
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| Abstract |
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The effects of nifedipne and verapamil were compared on carrageenan-induced paw edema in rats and the results are summarized as follows: Carrageenan induced severe acute paw edema within 30 minutes and the maximum effect was achieved around 4 hours after administration. The carrageenan-induced paw edema was prominantly reduced by pretreatments of indomethacin (2mg/kg, p.o.) and nifedipine (10 and 20mg/kg, i.p.), whereas verapamil had no effect on the carrageenan-induced paw edema. These results suggest that calcium antagonists, nifedipine and verapamil, have a different effect on the inflammatory response induced by carrageenan. |
| Key Words:
carrageenan, nifedipine, rat paw oedema, calcium antagonist |
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