Protective influence of selenium on nitrite-induced methemoglobinemia in rabbits |
Jin-sang Kim1, Jeong-hee Han1, Kye-soo Kim2 |
1College of Veterinary Medicine, Chonbuk National University 2Iri Agricultural High School |
가토(家兎)에서 nitrite에 의한 methemoglobinemia에 미치는 selenium의 영향(影響) |
김진상1, 한정희1, 김기수2 |
1전북대학교 수의과대학 2이리농고 |
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Abstract |
The protective of influences of sodium selenitc ($Na_2SeO_3$) against the methemoglobinemia with sodium nitrite were investigated on hemoglobin, methemoglobin, glutathione peroxidase and NADH-methemoglobin reductase activity in rabbits which were given 0,1,3 and 9ppm sodium selenite of drinking water for a week. Dietary selenium did not alter total hemoglobin in the blood of rabbits. Selenium was found to decrease nitrite-induced methemoglobin in a dose-dependent manner. The glutathione peroxidase activity was also increased by selenium in all the experimental groups. However, the NADH-methemoglobin reductase activity by selenite did not show significant differences as concerns the methemoglobinemia. These results showed that selenium could inhibit nitrite-induced methemoglobinemia. Its influence of inhibition is suggested that the effect of the reduction of methemoglobin was greatly stimulated by glutathione peroxidase activity. |
Key Words:
selenium, methemoglobin, glutathione peroxidase, methemoglobin reductase |
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