Korean Journal of Veterinary Research 1991;31(1):41-47.
Protective influence of selenium on nitrite-induced methemoglobinemia in rabbits
Jin-sang Kim1, Jeong-hee Han1, Kye-soo Kim2
1College of Veterinary Medicine, Chonbuk National University
2Iri Agricultural High School
가토(家兎)에서 nitrite에 의한 methemoglobinemia에 미치는 selenium의 영향(影響)
김진상1, 한정희1, 김기수2
1전북대학교 수의과대학
2이리농고
Abstract
The protective of influences of sodium selenitc ($Na_2SeO_3$) against the methemoglobinemia with sodium nitrite were investigated on hemoglobin, methemoglobin, glutathione peroxidase and NADH-methemoglobin reductase activity in rabbits which were given 0,1,3 and 9ppm sodium selenite of drinking water for a week. Dietary selenium did not alter total hemoglobin in the blood of rabbits. Selenium was found to decrease nitrite-induced methemoglobin in a dose-dependent manner. The glutathione peroxidase activity was also increased by selenium in all the experimental groups. However, the NADH-methemoglobin reductase activity by selenite did not show significant differences as concerns the methemoglobinemia. These results showed that selenium could inhibit nitrite-induced methemoglobinemia. Its influence of inhibition is suggested that the effect of the reduction of methemoglobin was greatly stimulated by glutathione peroxidase activity.
Key Words: selenium, methemoglobin, glutathione peroxidase, methemoglobin reductase


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