Korean Journal of Veterinary Research 1991;31(1):99-108.
Studies on the electrophoretic analysis of serum proteins in dogs infected with Babesia gibsoni
Dong-cheol Ihn, Joo-muk Lee, Joon-seok Chae, Hyeon-sung Cha
College of Veterinary Medicine, Chonbuk National University
Babesia gibsoni에 감염(感染)된 개의 혈청단백분획(血淸蛋白分劃)에 관한 연구
인동철, 이주묵, 채준석, 차현성
전북대학교 수의과대학
Abstract
To observe the changes of serum proteins according to the process of Babesia gibsoni(B gibsoni) infection, the babesia protozoa($10^8/kg$) were inoculated into the cephalic vein of healthy dogs. The serum proteins of experimentally infected dogs were separated by using cellulose acetate electrophoresis. The results obtained were as follows; 1. Cellulose acetate electrophoresis was fractionated to total 6 of bands such as, albumin, ${alpha}_1$, ${alpha}_2$, ${eta}_1$, ${eta}_2$ and $gamma$-globulin. 2. The concentration of total protein was shown a decreasing tendency after B gibsoni infection. Albumin and A/G ratio were lowered through all periods of the infection, but they were not significant changes. 3. The level of ${alpha}_1$-globulin was significantly(p<0.05) incresed in early stage of the infection. 4. The levels of ${alpha}_2$ and total $alpha$-globulin were shown highly significant decreases (p<0.01) through all periods of the infection. 5. The levels of ${eta}_1$ and total $eta$-globulin had highly significant changes (p<0.01) that was increased in early stage of infection and decreased later. 6. The level of $gamma$-globulin was seen to be constantly increased through all periods of infection. It was a highly significant change (p<0.01). 7. Plasma protein: fibrinogen (PP:F) ratio was shown a temporally significant increase (p<0.05) following the decrease in early infection.
Key Words: B gibsoni, cellulose acetate electrophoresis


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