| Source of Ca++ and effect of adenosine triphosphate on the isolated renal artery of pig |
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Yun-jeong Nam, Joo-heon Kim |
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College of Veterinary Medicine, Gyeongsang National University |
| 돼지 적출 신동맥에 대한 adenosine triphosphate의 영향과 Ca++의 동원 |
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남윤정, 김주헌 |
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경상대학교 수의과대학 |
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| Abstract |
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The aims of this study were to investigate the effect of adenosine triphosphate (ATP), which has been known as the neurotransmitter of nonadrenergic, noncholinergic nerves, and the source of $Ca^{sharp}$ in the effect of ATP on the isolated renal artery of pig. The results of this study were summarized as follows: 1. ATP caused the contraction and the contractile responses were increased in a dose-dependent manner between the concentration of ATP $2{ imes}10^{-3}M$ and $10^{-2}M$ on the isolated renal artery of pig. 2. The contractile responses induced by ATP $(5{ imes}10^{-3}M)$ were not blocked by pretreatment with cholinergic receptor blocker (atropine, $10^{-6}M$), $alpha$-adrenergic recptor blocker(phentolamine, $10^{-6}M$) or $eta$-adrenergic receptor blocker (propranolol, $10^{-6}M$), and $H_1$-receptor blocker (pyrilamine, $10^{-6}M$) or $H_2$-receptor blocker (cimetidine, $10^{-6}M$) on the isolated renal artery of pig. 3. The contractile responses induced by ATP $(5{ imes}10^{-3}M)$ were not appeared in $Ca^{sharp}$-free medium. As the concentration of $Ca^{sharp}$ in $Ca^{sharp}$-free medium was increased, the contractile responses induced by ATP $(5{ imes}10^{-3}M)$ were enhanced but were completely inhibited by pretreatment with $Ca^{sharp}$-channel blocker, papaverine $(5{ imes}10^{-5}M)$ or verapamil $(5{ imes}10^{-5}M)$ on the isolated renal artery of pig. |
| Key Words:
Adenosine triphosphate(ATP), receptor, pig renal, artery |
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