Korean Journal of Veterinary Research 1991;31(3):253-258.
Source of Ca++ and effect of adenosine triphosphate on the isolated renal artery of pig
Yun-jeong Nam, Joo-heon Kim
College of Veterinary Medicine, Gyeongsang National University
돼지 적출 신동맥에 대한 adenosine triphosphate의 영향과 Ca++의 동원
남윤정, 김주헌
경상대학교 수의과대학
Abstract
The aims of this study were to investigate the effect of adenosine triphosphate (ATP), which has been known as the neurotransmitter of nonadrenergic, noncholinergic nerves, and the source of $Ca^{sharp}$ in the effect of ATP on the isolated renal artery of pig. The results of this study were summarized as follows: 1. ATP caused the contraction and the contractile responses were increased in a dose-dependent manner between the concentration of ATP $2{ imes}10^{-3}M$ and $10^{-2}M$ on the isolated renal artery of pig. 2. The contractile responses induced by ATP $(5{ imes}10^{-3}M)$ were not blocked by pretreatment with cholinergic receptor blocker (atropine, $10^{-6}M$), $alpha$-adrenergic recptor blocker(phentolamine, $10^{-6}M$) or $eta$-adrenergic receptor blocker (propranolol, $10^{-6}M$), and $H_1$-receptor blocker (pyrilamine, $10^{-6}M$) or $H_2$-receptor blocker (cimetidine, $10^{-6}M$) on the isolated renal artery of pig. 3. The contractile responses induced by ATP $(5{ imes}10^{-3}M)$ were not appeared in $Ca^{sharp}$-free medium. As the concentration of $Ca^{sharp}$ in $Ca^{sharp}$-free medium was increased, the contractile responses induced by ATP $(5{ imes}10^{-3}M)$ were enhanced but were completely inhibited by pretreatment with $Ca^{sharp}$-channel blocker, papaverine $(5{ imes}10^{-5}M)$ or verapamil $(5{ imes}10^{-5}M)$ on the isolated renal artery of pig.
Key Words: Adenosine triphosphate(ATP), receptor, pig renal, artery


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