| Administration of ethylenethiourea during organogenesis periods in pregnant rats 2. Effects on water filled multiple T-maze test and α-fetoprotein, urea and free fatty acid concentrations in amniotic fluids |
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Sung-hoon Kim1, Rhin-soo Huh2 |
1Korea Research Institute of Chemical Technology
2Department of Veterinary Medicine, Kyungpook National University |
| Ethylenethiourea의 임신 랫트에 있어서 기관형성기 투여시험 2. 수 미로 시험과 양수내의 α-fetoprotein, 요소 및 유리지방산 함량에 미치는 영향 |
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김성훈1, 허린수2 |
1한국화학연구소
2경북대학교 수의과대학 |
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| Abstract |
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This study was carried out to investigate; the alpha-fetoprotein, urea and free fatty acid in amniotic fluids and water filled multiple T-maze test of fetuses affected by Ethylenethiourea. The S.P.F. Sprague-Dawley female rats(10 weeks) were used in this study and these animals were divided into four groups; control group I (10mg/kg/day), group II(30mg/kg/day), group III(50mg/kg/day). The results obtained were summarized as follows; 1. In the water filled multiple T-maze test of F1 male rats, The time and errors from start point to goal point of 30mg/kg group are significantly(p<0.001) increased from control group in 3rd day of test. In F1 female rats of 2nd day and 3rd day of water filled multiple T-maze test, The time and some errors in 30mg/kg group are significantly (p<0.05) increased from control group. 2. Alpha-fetoprotein values of all treated groups(10mg/kg, 30mg/kg and 50mg/kg) were significantly(p<0.001) decreased from control values in the amniotic fluids. 3. Urea values of ammniotic fluids in 50mg/kg group are significantly increased from control group. 4. Free fatty acid values of ammniotic fluids in 50mg/kg group are significantly increased from control group. |
| Key Words:
Ethylenethiourea, amniotic fluid, $alpha$-fetoprotein, urea, free fatty acid |
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