| Relaxation of P2-purinoceptor on isolated renal artery of rabbit |
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Joo-heon Kim1, Yong-keun Kim2 |
1College of Veterinary Medicine, Gyeongsang National University
2College of Medicine, Busan National University |
| 토끼 적출 신동맥에 있어서 P2-purinoceptor의 이완작용 |
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김주헌1, 김용근2 |
1경상대학교 수의과대학
2부산대학교 의과대학 |
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| Abstract |
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To elucidate the action of $P_2$-purinoceptor, effects of adenosine triphosphate(ATP) and perivascular nerve stimulation were investigated from polygraph in the isolated renal artery of rabbit 1. ATP caused the relaxation on the precontraction with noradrenaline$(10{mu}M)$ on the presene and absence of endothelium in the isolated renal artery of rabbit, the relaxative response was increased between 0.1 and $30{mu}M$ on dose-dependent manner. 2. The relaxative response induced by ATP$(10{mu}M)$ on precontraction with noradrenaline$(10{mu}M)$ was blocked by the pretreatment with reactive blue 2$(10{mu}M)$. 3. ATP inhibited the contractile response by perivascular nerve stimulation(0.3ms, 80V, 50Hz, 1 sec), the inhibitory action was blocked by the pretreatment with 8-phenyltheophylline$(10{mu}M)$. |
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