Spontaneous nephroblastoma in a New Zealand White rabbit : A case report

Kang, Booh-yon; Ha, Cbang-su

Korean Journal of Veterinary Research 1992;32(1):111-115.

Booh-yon Kang, Cbang-su Ha

Toxicology Research Center Korea Research Institute of Chemical Technology

New Zealand White 토끼의 신아세포종(Nephroblastoma) 자연발생례

강부현, 하창수

한국화학연구소 안전성연구센터

Abstract

A round, milkish white mass, approximately $4{ imes}4{ imes}5cm$ in size was found at the cranial part of the left kidney from a New Zealand White rabbit which was used as an untreated control animal in the safety evaluation test in the Toxicology Research Center, Korea Research Institute of Chemical Technology. The mass was lobulated and encapsulated. The cut surface revealed several round well-circumscribed lobules which were 0.5-3cm in diameter. No metastasis was observed. The microscopic features consisted of blastema and epithelial structures at variable stages of differentiation including primitive tubules, ducts, glomeruloid bodies. Normal mesenchymal cells were distributed among them. A diagnosis of nephroblastoma was made on the basis of the gross and microscopic features.

Key Words: Rabbit, Glomeruloid bodies, Blastema, Kidney tumor, Histopathology