Korean Journal of Veterinary Research 1992;32(2):217-225.
An occurrence of canine herpesvirus infection in Korea
Ok-jin Kim1, Ung-bok Bak1, Soo-hwan An2, Du-hee Kim2, Jin-ho Shin2
1College of Veterinary Medicine, Seoul National University
2Veterinary Research institute
Canine herpesvirus(CHV) 감염증의 자연발생예 관찰과 감염실험
김옥진1, 박응복1, 안수환2, 김두희2, 신진호2
1서울대학교 수의학과
Five puppies, 14 days old in the same litter showed acute symptoms such as painful crying, anorexia, abdominal pain and depression with fatal terminations. Necropsy of a puppy revealed hemorrhagic and necrotic foci in the lungs and kidney. The histological lesions were characterized with fibro-necrotizing foci in the lungs, nonsuppurative encephalitis and intranuclear inclusions of liver cells. A cytopathogenic agent was isolated from the thoracic fluid of a dead puppy by cell culture with primary dog kidney cells. The puppies inoculated with the field isolate showed the same clinical signs and lesions as those of the spontaneous cases. Viral particles were observed in suspension of the isolated agent by electron microscopy. The primary dog kidney cells infected with the field isolate showed fluorescent foci against anti-CHV monoclonal antibody after FA stain. On these findings of the disease it was diagnosed as CHV infection. The report signifies the first description of an epizootic of CHV infection in Korea.

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