Effect of Artemisia Iwayomogi water extract on hepatic injury by carbon tetrachloride in rats II. Effect on serum ALP, LAP activities, total protein, bilirubin content and liver glycogen content

Kim, Kil-soo; Park, Joon-hyoung

Korean Journal of Veterinary Research 1992;32(3):357-364.

Kil-soo Kim¹, Joon-hyoung Park²

¹ChoongAng Chemical Co., Ltd.
²Department of Veterinary Medicine, Kyungpook National University

사염화탄소에 의한 랫드의 간손상에 미치는 인진호추출물의 영향 II, 혈청내 효소(ALP, LAP) 활성도, 단백, bilirubin 함량 및 간내 glycogen 함량에 미치는 영향

김길수¹, 박준형²

¹중앙케미칼
²경북대학교 수의과대학

Abstract

Artemisia Iwayomogi Compositae) has been used clinically for jaundice, hepatitis, liver cirrhosis etc. The purposes of present study were to examine pharmacological effects of Artemisia Iwayomogi water extract(AIWE) on biochemical parameters (activities of ALP and LAP, contents of glucose, total bilirubin, total protein and albumin in serum, A/G ratio, and levels of hepatic glycogen) against hepatic injury by carbon tetrachloride($CCl_4$) in rats. The results were as follows ; 1. Increased ALP activities by $CCl_4$ were very significantly(p<0.001) decreased in AIWE posttreatment groups at 72 hours and significantly(p<0.05) decreased in AIWE pretreatment groups at 72 hours. Increased LAP activities by $CCl_4$ were significantly (p<0.05) decreased in AIWE posttreatment groups at 72 hours. A little increased total bilirubin contents by $CCl_4$ were very significantly (p<0.001) decreased in AIWE posttreatment groups at 24, 48 and 72 hours. 2. Increased glucose contents by $CCl_4$ were decreased in AIWE posttreatment groups. Decreased hepatic glycogen levels by $CCl_4$, were significantly (p<0.05) increased in AIWE posttreatment groups at 48 and 72 hours. 3. Decreased total protein contents by $CCl_4$ were significantly (p<0.05) increased in AIWE posttreatment groups at 48, 72 hours. Decreased albumin contents by $CCl_4$ were increased in proportion to numbers of AIWE treatments in AIWE pre- and posttreatement groups. Decreased A/G ratios by $CCl_4$ were significantly (p<0.05) increased in AIWE posttreatment groups at 48 hours. In conclusion, AIWE did not affect normal liver function and had hepatoprotective effects rather than direct preventive effects to $CCl_4$-induced cholestasis, damages in metabolisms of glucose, protein and bilirubin.

Key Words: Artemisia Iwayomogi Water Extract, carbon tetrachloride, hepatotoxicity, bilirubin