| Xylazine-induced depression and its antagonism by α-adrenergic blocking agents |
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Chung-hui Kim1, Dae-sik Hah2, Yang-mi Kim3, Jong-shu Kim1 |
1College of Veterinary Medicine, Gyeongsang National University
2Gyeongnam Provincial Government Institute of Health and Environment
3College of Medicine, Gyeongsang National University |
| Xylazine의 진정효과와 α-adrenergic 수용체 봉쇄약물의 길항효과 |
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김충희1, 하대식2, 김양미3, 김종수1 |
1경상대학교 수의과대학
2경남보건환경연구원
3경상대학교 의과대학 |
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| Abstract |
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The central nervous system depressant effect of xylazine and xylazine-ketamine was studied in chicken and mice. Intraperitoneal injection of xylazine(1~30 mg/kg) and xylazine(1~30 mg/kg)-ketamine(100 mg/kg) induced a loss of the righting reflex in chicken and mice, respectively. These effects of xylazine were dose-dependent. The results obtained were as follows; 1. The effect of xylazine-induced depression was antagonized by adrenergic antagonists having ${alpha}_2$-blocking activity(yohimbine, tolazoline, piperoxan and phentolamine). 2. Yohimbine was most effective in the reduction of the CNS depression by xylazine. 3. Phenoxybenzamine and prazosin did not reduced CNS depression by xylazine in both species. 4. Labetalol (${alpha}_1$, ${eta}_1$-adrenergic antagonist) and propranolol(${eta}$-adrenergic blocking agent) were not effective in reducing xylazine induced depression. 5. Cholinergic blocking agents (atropine and mecamylamine), a dopaminergic antagonist (Haloperidol), a histamine $H_1$-antagonist(chlorpheniramine), a histamine $H_2$-antagonist(cimetidine), a serotonergic-histamine $H_1$ antagonist(cyproheptadine) were not effective in reducing xylazine-induced depression. 6. Xylazine-induced depression is mediated by ${alpha}_2$-adrenergic receptors and appears not to be involved in cholinergic, dopaminergic, serotonergic or histaminergic pathways. |
| Key Words:
xylazine-ketamine, adrenergic, cholinergic, antagonist |
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