| Studies on the rabbit viral hepatitis II. Electron microscopic observation of the spleen in experimentally infected rabbit |
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Cha-soo Lee1, Young-ran Kwon1, Jong-sik Jyeong2, Tae-kyun Shin3 |
1College of Veterinary Medicine, Kyungpook National University
2Kyungpook Animal Health Experimental Institute
3Department of veterinary Medicine, Cheju National University |
| 토끼의 바이러스성 간염(肝炎)에 관한 연구(硏究) II. 실험적(實驗的) 오염(汚染) 토끼 비장(脾臟)의 전자현미경적(電子顯微鏡的) 관찰(觀察) |
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이차수1, 권영란1, 정종식2, 신태균3 |
1경북대학교 수의과대학
2경북가축위생시험소
3제주대학교 수의학과 |
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| Abstract |
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An acute fatal infectious disease in rabbits has been outbroken in Korea since 1985. This disease has been characterized as an acute hepatitis caused by viruses. However, viral pathogenesis in rabbit viral hepatitis leading to sudden death remain unclear. This report dealt with the electron microscopic findings on the spleen of experimentally infected rabbits, because spleen is one of the affected organs which have high titer of virus by a haemagglutination test. A typical crystalline array of virus was not found in the splenic cells of infected rabbits with acute hepatitis. Virus-like particles were seen within the phagosome of macrophages of the spleen. Ultrastructural changes in the spleen were severe with the lapse of time after inoculation. From these results, virus-like particles in the spleen were supposed to be phagocytosed by macrophage during viremia, while active replication of virus occurred in the liver. It was concluded that sudden death in this viral disease was caused by hepatic coma and/or circulatory disturbance. |
| Key Words:
rabbit, haemorrhagic disease, viral hepatitis, spleen, electron microscopy |
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