| Effect of cholinergic and α2-adrenergic nerve on the isolated dog ileal smooth muscle by the electrical field stimulation |
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Joo-heon Kim1, Cheol-soo Shim2, Sang-eun Park3 |
1College of Veterinary Medicine, Gyeongsang National Universtiy
2Eastern Branch, Gyeongnam Animnal Health Institute
3Central Branch, Gyeongnam Animnal Health Institute |
| 개 적출 회장 평활근의 field stimulation에 의한 cholinergic 및 α2-adrenergic 신경의 효과 |
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김주헌1, 심철수2, 박상은3 |
1경상대학교 수의과대학
2경상남도 가축위생시험소 동부지소
3경상남도 가축위생시험소 중부지소 |
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| Abstract |
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To elucidate the action of the cholinergic and ${alpha}_2$-adrenergic nerve on the isolated ileal smooth muscle of the dog, effect a of electrical field stimulation were investigated on the pretreatment of the physostigmine; cholinestrase inhibitor, yohimbine; ${alpha}_2$-adrenoceptor blocker, atropine ; cholinergic receptor blocker and phentolamine; non-selective $alpha$-adrenoceptor blocker from physiograph. 1. The contractile response induced by electrical field stimulation was the frequency (2-40 Hz)-dependent manner. 2. The contractile response induced by electrical field stimulation was markedly increased by the pretreatment of physostigmine$(1{mu}M)$; cholinestrase inhibitor. 3. The contractile response induced by electrical field stimulation was increased by the pretreatment of yohimbine$(1{mu}M)$; ${alpha}_2$-adrenoceptor blocker. These finding suggest that it was powerful excitatory action by cholinergic nerve and inhibitory action by ${alpha}_2$-adrenergic nerve on ileal smooth muscle of the dog. |
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