Korean Journal of Veterinary Research 1993;33(3):507-511.
The effect of captafol on the hematological value, erythrocyte membrane and plasma biochemical value in vitro
Sung-hoon Kim, Hwa-seon Hwang, Shin-woo Cha, Sang-seop Han, Jung-koo Roh
Toxicology Research Center Korea Research Institute of Chemical Technology
시험관내에서 captafol이 혈액학, 적혈구막 및 혈장생화학치에 미치는 영향
김성훈, 황화선, 차신우, 한상섭, 노정구
한국화학연구소 안전성연구센터
Abstract
The effect of captafol on the hematological value, erythrocyte membrane and plasma biochemical value was investigated using blood of SPF Sprague-Dawley male rats in vitro. For the anticoagulations, we used 0.5mg of heparin per $10m{ell}$ of blood from vena cava. Three con-centrations($0.1{ imes}10^{-4}M$, $1{ imes}10^{-3}M$ and $1{ imes}10^{-2}M$) captafol in ethanol were added to the each $2.5m{ell}$ blood so that the linal concentration of ethanol was 1%. The blood contained with each concentration of captafol was incubated at $37^{circ}C$ C for 2 hours under 5% $CO_2$ gas The whole blood and plasma were examined for hematological vaJues, erythrocyte membrane damage and biochemical values, respectively. The results obtained were summarized as follows ; 1. The number of RBC in $1{ imes}10^{-2}M$ group and the concentration of MCHC in $1{ imes}10^{-3}M$ group were significantly (p<0.05) decreased and increased from that of control values, respectively. The percentage of Hct was significantly (p<0.05) decreased with dose-response. 2. Erythrocyte fragility rate of $1{ imes}10^{-3}M$ and $1{ imes}10^{-2}M$ group were significantly (p<0.01) increased from that control with dose response. 3. Potassium ion level of $1{ imes}10^{-2}M$ was significantly (p<0.05) increased from that of control. 4. The concentration of total bilirubin in the $1{ imes}10^{-3}M$ and $1{ imes}10^{-2}M$ groups were significantly increased from that of control. The enzyme level of creatine kinase in $1{ imes}10^{-2}M$ group was significanlty (p<0.05) decreased from control value.
Key Words: captafol, hematological value, erythrocyte membrane, plasma biochemical value, in virto


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