Korean Journal of Veterinary Research 1993;33(4):633-647.
Morphopathogenesis o the abscess induced by Dermatophilus-like microorganism in mice
Chang-su Ha1, Ung-bok Bak2
1Toxicology Research Center, Korea Research Institute of Chemical Technology
2College of Veterinary Medicine, Seoul National University
마우스에 있어서 Dermatophilus 양 균에 의한 농양의 형태 병리 발생
하창수1, 박응복2
1한국화학연구소 안전성연구센터
2서울대학교 수의과 대학
NC strain mice were inoculated intraperitoneally with Dermatophoilus-like microorganism strain W254 isolated from the sulfur granules of the swine tonsils. The development of the resulting abscesses in NC strain mice was investigated at regular time intervals by means of histological, histochemical and electron microscopical methods. The results obtained were as follows ; 1. The inoculated bacteria have settled in the subserous site of the peritoneal organ and provoked cellular response to form neutrophil, macrophage and connective tissue layers at the time of one week after inoculation, and thereafter were found to have formed typical actinomycotic abscess two weeks after inoculation. 2. The persistant abscesses were appeared to reveal close interaction between higher activity of organism and tissue reaction and contained hyaloid bodies within or outside bacterial clumps. 3. The hyaline materials were appeared to be composed of protein rich in hydroxyphenyl group by histochemical examination. The materials were presumed to be produced by the interaction between bacterial activity and host cell reaction. 4. The bacteria in the abscesses showed the various developmental stages of coccoid body, mulberry-like body tuber-shaped body and filamentous body, and it was confirmed that the mesosomal development was related to septation of the bacterial cells.
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