Korean Journal of Veterinary Research 1993;33(4):679-691.
Effect of immunosuppression on Ascaris suum infection in undefinitive hosts I. Investigations in rabbits
Jae-ku Rhee, Chang-hyun Lee, Bae-keun Park, Sang-bork Lee
College of Veterinary Medicine, Chonbuk National University
비고유숙주(非固有宿主)에 있어서 면역억제(免疫抑制)가 돼지 회충(蛔蟲)의 감염(感染)에 미치는 영향(影響) I. 집토끼에서의 실험소견(實驗所見)
이재구, 이창현, 박배근, 이상복
전북대학교 수의과대학
As a series of studies to investigate the effect of immunosuppression on Ascaris suum infection in undefinitive hosts, a delicate relationship between host and parasite, rabbits were divided into experiment 1(control group) and experiment 2(immnunosuppressive group treated with prednisolone acetate) and inoculated with a single dose of 5,000 embryonated A suum eggs. The recovery rates, sizes and morphology of the larvae and immunological responses in the rabbits were chronologically monitored according to somatic migration. In both experiments, the larvae failed to develop into the adults, but young adults in the experiment 2 grew somewhat faster and survied later than those in the experiment 1. The mast cells of small intestinal mucosa and mesenteric lymph nodes and the goblet cells of small intestinal mucosa in the worm detected cases of experiment 2 decreased remarkably in number comparing with those of experiment 1. Considering the experimental results. the expulsion mechanism of somatic migrant larvae may he related to the temporary increasing tendency of the mast cells, the goblet cells, T-cells of mesenteric lymph nodes and spleens, eosinophils in peripheral blood, degranulation rates of peritoneal mast cells and the migration inhibition rates of leucocytes. In addition, patent infection of A suum in the rabbits was not obviously observed despite of immunosuppression by prednisolone acetate.
Key Words: ascaris suum, immunosuppression, patent infection, rabbit

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