| Pharmacokinetics of oxytetracycline in rabbits after intravenous and intramuscular administrations |
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Eun-jung Kim1, Hyo-in Yun1, Seung-chun Park1, Tae-kwang Oh2, Chun-hyung Cho3 |
1Colleage of Veterinary Medicine, Chungnam National University
2Genetic Engineering Research Institute, KAIST
3Veterinary Research Institute |
| 토끼에서 oxytetracycline의 정맥 및 근육 투여시의 약물동태학 |
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김은정1, 윤효인1, 박승춘1, 오태광2, 조준형3 |
1충남대학교 수의과대학
2한국과학기술원 유전공학연구소
3가축위생연구소 |
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| Abstract |
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The study was carried out to determine the pharmacokinetic parameters after intravenous(iv) and intramuscular(im) administration (10mg/kr) in healthy rabbits. The results obtained through the experiments were summarized as follows: 1. Bioassay (Bacillus cereus 11778) was evaluated very useful for the determination of oxytetracycline(OTC) in the rabbit serum and tissues, with the detection limit of $0.125{mu}g/ml$. 2. The pharmacokinetic profiles of OTC (10mg/kg, iv) in rabbits were best described with a two compartment open model $(C=29.5e^{-4,3t}{pm}3.6^{-0.2t})$, whereas that of OTC (10mg/kg, im) showed a one compartment curve fitting. 3. Following iv administration, a rapid distribution phase was predominant [$t_{frac{1}{2}}({alpha}):1.43{pm}0.98hr$ (♂), $0.5{pm}0.1hr$(♀)], and then more slow elimination phase ensued [$t_{frac{1}{2}}({eta}):4.52{pm}0.76hr$(♂), $7.32{pm}2.52hr$(♀)]. Other computer generated pharmacokinetic values were as follows:C1 [$67.76{pm}18.59ml/kg/h$(♂), $76.03{pm}22.98ml/kg/h$ (♀)] Vd [$257.74{pm}180.47ml/kg$ (♂), $92.33{pm}23.62$ (♀)] AUC [$25.6{pm}4.44mgh/L$ (♂), $39.6{pm}12.13mgh/l$ (♀)]. There were no statistical significance between both sexes for all the parameters at the confidence level of 95%. 4. After im administaration, the absorption from the injection sites was very rapid [ Ka:$0.18{pm}0.03h^{-1}$ (♂), $0.24{pm}0.02h^{-1}$ (♀)] followed by a monoexponential elimination fashion. The time to peak blood level (Tmax) were calculated $1.64{pm}0.15hr$ and $1.34{pm}0.24hr$, in the male and female, respectively. The peak levels (Cmax) at the corresponding time were $1.69{pm}0.23{mu}g/ml$ (♂) and $2.08{pm}0.16{mu}g/ml$ (♀), with no statistical differences (p>0.05). |
| Key Words:
oxytetracycline, rabbit, pharmacokinetics, compartment, elimination |
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