Effects of serum on lymphokines producing capabilities of CD8+ T cells |
Si-yun Ryu1, Won-kee Yoon1, Sung-whan Cho1, Moo-kang Kim1, Tae-hwan Kim2 |
1College of Veterinary Medicine, Chungnam National University 2Laboratory of Radiation Medicine, Korea Cancer Center Hospital |
Serum이 CD8+ T cell의 lymphokine 생산양상의 변화에 미치는 영향 |
류시윤1, 윤원기1, 조성환1, 김무강1, 김태환2 |
1충남대학교 수의과대학 2한국원자력병원 방사선의학연구실 |
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Abstract |
The responsiveness of $CD8^+$ T-cell subpopulation according to serum-containing and serum-free conditions were investigated. Cells are freshly isolated from spleen of mature adult BALB/C mice between 13-20 weeks of age. $CD8^+$ T cells in serum-free conditions produce small amounts of IL-2, while significant amounts of IFNr following activation when compared the results of serum-containing conditions. These data indicate that serum-derived factors may play an important role in the alternations of $CD8^+$ T cell responsiveness. |
Key Words:
$CD8^+$ T cell, IL-2, IL-4, IFNr |
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