| Effect of immunosuppression on Ascaris suum infection in undefinitive hosts III. Investigations in mice |
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Jae-ku Rhee, Bae-keun Park, Beung-gui Jang, Sim-yong Yook |
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College of Veterinary Medicine, Chonbuk National University |
| 비고유숙주(非固有宿主)에 있어서 면역억제(免疫抑制)가 돼지회충(蛔蟲)의 감염(感染)에 미치는 영향(影響) III. 마우스에서의 실험소견(實驗所見) |
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이재구, 박배근, 장병귀, 육심용 |
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전북대학교 수의과대학 |
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| Abstract |
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As a series of studies to investigate the effect of immunosuppression on Ascaris suum infection in undefinitive hosts, and a delicate relationship between host and parasite, in the present studies, SPF ICR mice were alloted to experiment 1(normal undefinitive host group) and experiment 2(immunosuppressive group treated with prednisolone acetate) and inoculated with a single dose of 1,100 embryonated A suum eggs. In normal group, the infection essentially terminates 4 days after inoculation(DAI) with the attainment of middle third-stage in the liver, although few larvae migrate to the lungs where a few advance to late third stage. In immunosuppressive group, significant numbers developed to late third-stage in liver 8 DAI. In general, increasing of the mast cells and the goblet cells in the jejunum mucosa, of T-cells in the spleen and of activity of peritoneal macrophages followed by expulsion of the worms in the both groups. Considering a series of the results, suitabilities for the host of the worm appeared the highest from rabbit, hamster and mouse in that order. In addition, patent infection of A suum in the mice was also not obviously observed in spite of immunosuppression by prednisolone acetate. |
| Key Words:
Ascaris suum, immunosuppression, host-parasite relationship, mouse |
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