| Effect of calcitonin gene-related peptide, vasoactive intestinal peptide and substance P on isolated renal artery of rabbit |
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Joo-heon Kim1, Cheol-soo Shim2, Sang-eun Park3 |
1College of Veterinary Medicine Gyeongsang National University
2Eastern Branch Gyeongnam Animal Health Institute
3Central Branch Gyeongnam Animal Health Institute |
| 토끼 적출 신동맥에 대한 calcitonin gene-related peptide, vasoactive intestinal peptide 및 substance P의 효과 |
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김주헌1, 심철수2, 박상은3 |
1경상대학교 수의과대학
2경상남도 가축위생시험소 동부지소
3경상남도 가축위생시험소 중부지소 |
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| Abstract |
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To elucidate the effect of calcitonin gene-related peptide(CGRP), vasoactive intestinal peptide(VIP) and substance P was investigated with perivascular nerve stimulation and treatment of peptides from polygraph in the isolated renal artery of rabbit. 1. The neurogenic contraction induced by perivascular nerve stimulation was the frequency-dependent manner(264 Hz) in the isolated renal artery of rabbit. 2. CGRP and VIP caused the relaxation on the precontraction with noradrenaline($10{mu}m$) on the presence and absence of endothelium in the isolated renal artery of rabbit. 3. Substance P caused the endothelium-dependent relaxation on the precontraction with noradrenaline($10{mu}m$) in the isolated renal artery of rabbit. 4. CGRP and VIP inhibited the neurogenic contraction by the perivascular nerve stimulation(0.3 ms, 80 V, 50 Hz, 1 sec) on the absence and presence of endothelium in the isolated renal artery of rabbit. 5. Substance P inhibited on the neurogenic contraction by the perivascular nerve stimulation with the endothelium-dependent in the isolated renal artery of rabbit. |
| Key Words:
calcitonin, gene-related peptide, substance P, rabbit |
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