Morphological changes of Schwann cells as neurotoxic responses

Rim, Byung-moo; Chae, Hyun-sok; Lee, Oh-hyung

Korean Journal of Veterinary Research 1994;34(4):801-804.

Byung-moo Rim, Hyun-sok Chae, Oh-hyung Lee

Bio-Safety Research Institute, Chonbuk National University

신경독성에 의한 Schwann 세포의 형태적 변화

임병무, 채현석, 이오형

전북대학교 생체안전성 연구소

Abstract

The early change observed in lead-induced neurophathy in the rat was Schwann cell swelling. In order to quantify this cell swelling, Schwann cell thickness and major diameter of the nucleus were measured using tranverse section with associated myelinated fiber of sciatic nerves. Group I rats were intoxicated with 0.5% lead acetate in the drinking water for 30 days; group II animals were treated as in group I and then restored to normal laboratory conditions for 30 days; and group III were controls. The results showed that the cell sizes were significantly greater in intoxicated animals, compared with control, and the cell sizes of group II did not differ significantly from control rats.

Key Words: Schwann cell, neuropathy, lead acetate, myelinated fiber