| Effects of administration of Lactobacillus acidophilus-fermented milk on hematological values and histopathological changes of kidney in cadmium-treated rats |
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Young-chae Cho1, Moo-hyung Jun2, Kyung-soo Chang2 |
1College of Medicine, Chungnam National University
2College of Veterinary Medicine, Chungnam National University |
| Lactobacillus acidophilus 발효유가 cadmium투여된 흰쥐의 혈액상과 신장조직에 미치는 영향 |
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조영채1, 전무형2, 장경수2 |
1충남대학교 의과대학
2충남대학교 수의과대학 |
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| Abstract |
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To elucidate the protective effects of Lactobacillus acidophilus-fermented milk against cadmium toxicity, the effects of administration of L acidophilus-fermented milk on hematological values and histopathological changes in cadmium-treated rats were investigated. The experimental rats were divided into 2 groups that were consisted of the one group administered with cadmium alone, and the other group administered with cadmium mixed with the fermented milk. Each group was orally administered with different doses of cadmium such as $1.7{mu}g/g$ bw/day, $3.4{mu}g/g$ bw/day, $6.8{mu}g/g$ bw/day, and $13.6{mu}g/g$ bw/day, respectively, for 1 to 8 weeks. Hematological values and enzyme activities, histopathological changes of kidney tissues were examined for the experimental groups. The values of RBC, WBC, and Hb in the groups administered with cadmium mixed with the fermented milk showed no significant differences to those of the groups administered with cadmium alone, but Hct showed significant reducing values. The activities of glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase (GPT) in serum were significantly reduced than those of the groups administered with cadmium alone, at the low dose of cadmium treated groups. But alkaline phophatase(ALP) and lactate dehydorgenase(LDH) were significantly reduced at the high dose of cadmium treated groups. In histopathological study, a severe acute tubular necrosis of the convoluted tubules and distalation of tubules were showed in the groups administered with cadmium alone, but the kidney tissues of the groups administered with cadmium mixed with the fermented milk were similar to those of the normal group. In conclusion, the above results would suggest that L acidophilus-fermented milk has reducing effects on cadmium toxicity, at the low dose of cadmium administration. |
| Key Words:
administration of L acidophilus-fermented milk and cadmium, hematological values, histopathological changes |
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