| Activity and application of 20α-hydroxysteroid dehydrogenase in rat 1. Changes in activities of 20α-hydroxysteroid dehydrogenase and serum progesterone concentration |
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Chung-boo Kang, Soo-dong Kwak |
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College of Veterinary Medicine, Gyeongsang National University |
| Progesterone의 이화(異化)효소, 20α-hydroxysteroid dehydrogenase의 활성 및 활용에 관한 연구 1. 20α-hydroxysteroid dehydrogenase의 활성 및 혈청 progesterone 농도의 변화 |
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강정부, 곽수동 |
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경상대학교 수의과대학 |
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| Abstract |
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Progesterone catabolizing enzyme, the enzyme $20{alpha}$-hydroxysteroid dehydrgenase($20{alpha}$-HSD) is pivotal in the regulation of ovarian function in rodents, which catabolizes progesterone into biologically inactive $20{alpha}$-hydroxypregn-4-en-3-one($20{alpha}$-OHP). In this study was carried out the influence of $20{alpha}$-HSD activity of ovarian function, we investigated changes in ovarian cytosol $20{alpha}$-HSD activity and serume progesterone concentration during the estrous cycles and pregnancy in rat. During the estrous cycles, the $20{alpha}$-HSD activities were highest on the progestrous, but serum progesterone concentration was lowest on this phase. During the pregnancy, the $20{alpha}$-HSD activities were relatively higher early pregnancy(day-1-3 gestation) and late pregnancy(day 21 to parturition), serum progesterone concentration was maintained significantly high to day 19 of gestation. The $20{alpha}$-HSD activities were lower during the middle pregnancy. From these results, ovarian $20{alpha}$-HSD activities may possibly act as physiologically very important in the control and maintenance of estrous cycles in rat. |
| Key Words:
$20{alpha}$-hydroxysteroid dehydrogenase($20{alpha}$-HSD), catabolizing enzyme, $20{alpha}$ hydroxypregn-4-en-3-one($20{alpha}$-OHP), progesterone, rat |
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