Korean Journal of Veterinary Research 1995;35(1):107-113.
Experimental cryptosporidiosis in calves
Sung-hwan Wee1, Chung-gil Lee2, Yung-bai Kang1, Hoo-don Joo1, Yi-seok Joo1, Yong-ho Park1, Sang-ho Choi1
1National Veterinary Research Institute, RDA
2College of Veterinary Medicine, Chonnam National University
송아지의 실험적 크립토스포리디움증
위성환1, 이정길2, 강영배1, 주후돈1, 주이석1, 박용호1, 최상호1
1수의과학연구소
2전남대학교 수의과대학
Abstract
Four Holstein calves 7-day-old were infected with C parvum oocysts for parasitological and pathological investigations of bovine cryptosporidiosis. Of those calf 1 was orally administered with $7{ imes}10^6$ oocysts of C parvum isolated from a Korean mouse (VRI-CN91), and calf 2 with same number of C parvum oocysts provided by Washington State University(WSU). The rest (calf 3 and 4) were orally administered with $1{ imes}10^8$ oocysts of VRI-CN91 strain. Calf 1 commenced to discharge oocysts in feces at days 6 post inoculation(PI), and it reached a peak $1.4{ imes}10^7$ oocysts per gram of feces(OPG) on day 8 PI. Calf 2 commenced to discharge oocysts in feces at day 4 PI, and it reached a peak $3.75{ imes}10^6$ OPG on day 7 PI. Calf 3 and 4 commenced to discharge oocysts in feces at day 3 and day 4 PI, and it reached a peak on day 7 PI (calf 3, $7.8{ imes}10^6$ OPG; calf 4, $1.7{ imes}10^6$ OPG). Clinically, the calves began to show mucoid-watery diarrhea at day 3 to 5 PI, and the sign lasted 5 to 7 days. Calf 2 died on day 9 PI with a severe dehydration. On necropsy the intestine was found to be congested and hemorrhagic. Protozoan oocysts were observed mainly in the ileum and occasionally in jejunum. The results in the present study indicate that the Korean isolate was pathogenic in calves.
Key Words: cryptosporidiosis, Cryptosporidium parvum, diarrhea, calves


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