Korean Journal of Veterinary Research 1995;35(1):123-130.
Anticoccidial effects of artemisinin on the Eimeria tenella
Hwa-gyun Oh1, Hee-jeong Youn1, Jae-wuk Noh2, Du-hwan Jang1, Yung-bai Kang3
1Dept. of Parasitology, College of Vet. Medicine, Seoul National University
2Bayer Veterinary Medical Research Institue, Bayer Vetchem(Korea)
3Veterinary Research Institute in RDA
Artemisinin의 Eimeria tenella에 대한 항콕시듐 효과
오화균1, 윤희정1, 노재욱2, 장두환1, 강영배3
1서울대학교 수의과대학 기생충학교실
2한국바이엘화학(주) 동물의약연구소
Artemisinin, a sesquiterpene lactone, is isolated from the leafy portion of the Artemisia annua and has been known to be effective against Plasmodium species. Since the genera of Plasmodium and Eimeria(E) tenella are included the same order, Eucoccidiidae, it is presumed that artemisinin may also be effective against E tenella. In order to study the anticoccididal effects of artemisinin, the chickens inoculated with E tenella were treated with artemisinin at different concentrations as feed additive and the results were compared to those of non-medicated, infected control(NIC) and non-medicated, non-infected control(NNC) group. Artemisinin demonstrated anticoccidial effects by showing, compared to NIC group, improved results in all parameters, such as bloody diarrhea, lesion scores, the numbers of excreted oocystis in feces, body weight gain and feed conversion rate. Anticoccidial index(ACI) of artemisinin treated group (5ppm~50ppm) was higher than that of NIC group. Improvements were greatest in the group treated with artemisinin 50ppm with an ACI of 147.6. These results indicate that artemisinin has anticoccidial effects on the Eimeria tenella.
Key Words: Artemisinin, Eimeria tenella, anticoccidial effects, anticoccidial index

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