Cholinergic contraction to the perivascular nerve stimulation on the isolated coronary artery of pig |
Cheol-soo Shim1, Sang-eun Park2, Seok-cheol Jeon3, Bang-keun Han4, Joo-heon Kim5 |
1Eastern Branch, Gyeongnam Animal Health Institute 2Central Branch, Gyeongnam Animal Health Institute 3Cardiac Center, Masan Koryo General Hospital 4College of Veterinary Medicine, Chonnam National University 5College of Veterinary Medicine, Gyeongsang National University |
돼지 적출 심관상동맥에 있어서 perivascular nerve stimulation에 의한 cholinergic 수축 작용 |
심철수1, 박상은2, 전석철3, 한방근4, 김주헌5 |
1경상남도 가축위생시험소 동부지소 2경상남도 가축위생소 중부지소 3마산고려병원 심장센터 4전남대학교 수의과대학 5경상대학교 수의과대학 |
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Abstract |
The effects of various autonomic blocking agents to perivascular nerve stimulation were investigated on isolated coronary artery of pig. 1. The magnitude of contractile response to perivascular nerve stimulation increased with increasing frequency(280Hz) of stimulation. 2. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) were increased by pretreatment of the cholinestrase inhibitor, physostigmine. 3. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) was antagonised by the muscarinic antagonist, atropine. 4. The contraction to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) was blocked by the neural blocker, tetrodotoxin. 5. The contractions to perivascular nerve stimulation(40V, 40Hz, 0.5msec, 1min) were not significantly affected by the ${alpha}$-adrenergic antagonist, phentolamine or ${eta}$-adrenergic antagonist, propranolol. 6. The contractile response by the acetylcholine was increased by the pretreatment of cholinestrase inhibitor, physostigmine. This findings suggest that the powerful excitatory action by the perivascular nerve stimulation may be linked to muscarinic receptor by cholinergic nerve excitation in coronary artery of pig. |
Key Words:
acetylcholine, physostigmine, perivascular nerve stimulation, coronary artery, pig |
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