Korean Journal of Veterinary Research 1995;35(2):255-261.
Effect of amitraz on intestinal contractility
Dong-ho Shin1, Chae-mi Lim1, Jae-ha Kim2
1College of Veterinary Medicine, Chonnam National University
2College of Medicine, Chonnam National University
장평활근의 수축성에 대한 amitraz의 영향
신동호1, 임채미1, 김재하2
1전남대학교 수의과대학
2전남대학교 의과대학
Abstract
Amitraz frequently causes the side effect of intestinal stasis or bloat in mammals. It is very similar to the side effect of xylazine or clonidine which produce the inhibition of intestinal motility through the stimulation of ${alpha}_2$ adrenoceptor. Therefore, we examined whether amitraz causes intestinal stasis or bloat through the inhibition of intestinal motility or whether amitraz produces the inhibition of intestinal motility through the stimulation of ${alpha}_2$ adrenopceptor. Amitraz inhibited the intestinal motility in a dose-dependent manner in isolated rabbit jejunum and isolated pig ileum. These inhibitory effects of amitraz were blocked by yohimbine but not by prazosin. The effect of intestinal contraction of carbachol or high-potassium was not affected by the pretreatment of amitraz. However, the con-traction of histamine was inhibited by the pretreatment of amitraz. It is concluded that amitraz mainly inhibits the intestinal motility through the stimulation of ${alpha}_2$-adrenoceptor although partially antihistaminic action of amitraz can be involved.
Key Words: amitraz, ${alpha}_2$-adrenoceptor, isolated intestinal segment


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