| Characterization of major histocompatibility complex antigen on Korean native cattles |
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Seok-joo Yoon, Myung-sang Kwon |
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Department of Veterinary Medicine, College of Animal Agriculture, Kangwon National University |
| 한우의 주요 조직 적합성 항원 규명 |
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윤석주, 권명상 |
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강원대학교 축산대학 수의학과 |
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| Abstract |
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The characterization of the MHC of domestic animals may constitute a first step towards increasing the efficiency of food production through improved disease resistance. In order to study the role of the MHC in regulating immune response it is first necessary to identify the different MHC alleles. In this research we try to investigate the possible associations between BoLA of Korean native cattles and infectious cattle disease. For this purpose we used one approach, serology. The results were summarized as follows : 1. Korean native cattle's lymphocyte reacted with alloantisera which recognized seven official BoLA allele. Korean native cattle's lymphocytes were reacted same as European breeds(especially with 673/3(W20)). 2. Korean native cattle's lymphocytes reacted with alloantisera 773/2, 673/3, 638/3, 773/3, 602/2, 639/2 and 639/3 at high reaction frequency. But alloantisera 642/1 was not expressed on Korean native cattle. If this allele, recognized by alloantisera(642/1), officially certificate In BoLA workshop it will be characterization factor of Korean native cattle. 3. According to cellular similarity index, we can presume on genetic relativity which has no family relationship. |
| Key Words:
BoLA, Korean native cattle, HLA test |
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