Effects on the pathogenicity and the immunogenicity of Eimeria tenella to the chickens treated with dexamethasone and testosterone propionate and on the relation with antibody titers for Newcastle disease virus

Youn, Hee-jeong; Noh, Jae-wuk; Oh, Hwa-gyun

Korean Journal of Veterinary Research 1995;35(2):337-345.

Hee-jeong Youn¹, Jae-wuk Noh², Hwa-gyun Oh³

¹College of Veterinary Medicine, Seoul National University
²Bayer Veterinary Medical Research Institute, Bayer Vetchem
³Central Research Institute, Dept. of Chem. Lab, Taihan Sugar Industrial Co., Ltd.

덱사메타손과 테스토스테론 호르몬으로 처리된 닭에서 Eimeria tenella의 병원성 및 면역원성과 뉴캣슬병 바이러스에 대한 항체가의 비교

윤희정¹, 노재욱², 오화균³

¹서울대학교 수의과대학
²한국바이엘화학(주) 동물의약연구소
³대한제당(주) 중앙연구소 발효연구실

Abstract

To evaluate the pathogenicity and immunogenicity of Eimeria tenella to the chicken treated with dexamethasone(DEX) and testosterone propionate (TES), we administered 0.1ml/chicken of dexamethasone and 40mg/chicken of testosterone propionate at 1-, 2-, and 7-days old, respectively. We also immunized with ND oil-emulsion vaccine at 2 weeks old. After that, we immunized and challenged with 100 and $1{ imes}10^5$ oocysts/chicken of E tenella at 2 and 4 weeks old, respectively. And then we investigated the HI titers for ND virus, survival rate, body weight gain, lesion score and the weight of the bursa of Fabricius and thymus. The titers for ND virus in the groups treated with TES were higher than those in the groups treated with DEX and CON during 3 to 6 weeks. After challenge, the survival rate of testosterone propionate treated-challenged(TES-CHA) and TES-immunized and challenged(TES-V&C) groups were 61.5 and 83.3% and those of the other groups were all 100%. At 1 week after challenge, the lesion scores of TES-CHA group(4.0) was the highest of all experimental groups. Those of DEX and controlchallenged( CON-CHA) groups were 2.8, and those of all V&C groups were 2.4. During 1 and 2 weeks after immunization, the body weight gains of TES groups were severe low(61.6-82.2g and 189.6-260.4g). During 1 and 2 weeks after challenge, the body weight gains of all CHA groups were lower than those of not challenged groups. But, those of all V AC groups were not different from those of not immunized groups. At 4- and 6-weeks old, the weight of the bursa of Fabricius and thymus in the chicken of all TES groups were lower than those of all control (CON) and DEX groups. Therefore, testosterone propionate acted as immunosuppressive drug. Also, it was thought that the chicken affected a little humoral immunity to E tenella.

Key Words: Eimeria tenella, pathogenicity, immunogenicity, dexamethasone, testosterone propionate, Newcastle disease virus antibody titers