| Studies on isolation of rhinopneumonitis virus from Korean horses and its immunogenicity III. Studies on immunogenicity of equine herpesvirus in experimental animals |
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Gil-jae Cho1, Bong-hwan Kim2, Sin-hee So2, Du-sik Lee3 |
1Korean Racing Association, Cheju Race Course
2College of Veterinary Medicine, Kyungpook National University
3Department of Veterinary Medicine, Cheju National University |
| 국내 말로부터 비폐렴바이러스의 분리 및 면역원성에 관한 연구 III. 말 비폐렴바이러스의 실험동물에 대한 면역원성 조사 |
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조길재1, 김봉환2, 소신희2, 이두식3 |
1한국마사회 제주경마장
2경북대학교 수의과대학
3제주대학교 수의학과 |
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| Abstract |
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The study was carried out to investigate the pathogenicity of EHV isolate to hamsters and mice and immunogenicity of experimentally produced. vaccine were evaluated in the horses. Hamsters infected. intranasally with $LC_1$ isolate showed symptoms of nasal discharge, conjunctivitis and body weight loss during the observation period of 12 days after infection, while only slight depression and body weight loss were noticed with mice infected with $LC_1$ indicating that hamsters are more susceptible to the virus. Antibody titer of mice and hamsters were gradually increased to highest level of 1:2560~10240, 1:640~1280, respectively, at 7~12 days post vaccination. Horses immunized against $LC_1$ killed vaccine reached to maximum antibody titer of 1:20480 around 4 weeks after 1st vaccination and declined after 12 weeks post vaccination. No significant antibody increase were detected after 2nd vaccination. Mean body temperature and mean total leukocyte counts remained within normal range and no adverse reaction were noticed after vaccination. |
| Key Words:
EHV, hamster, nasal discharge, conjunctivitis, mice |
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