Korean Journal of Veterinary Research 1996;36(1):57-63.
Effect of anticancer drug methortrexate on the biliary excretion kinetics of the reudced folate derivatives in rats
Ho-chul Shin1, Shin-woo Cha1, Ju-hyun Bae1, Hyun-ju Kim1, Tae-cheon Jeong1, Jong-il Park1, Jong-man Yoon2, Gye-woong Kim2, Jin-suk Kim2, Sang-seop Han1
1Korea Research Institute of Chemical Technology
2Kon-Kuk University
항암제 methotrexate가 랫드 담즙중 환원형엽산유도체의 배설동태에 미치는 영향
신호철1, 차신우1, 배주현1, 김현주1, 정태천1, 박종일1, 윤종만2, 김계웅2, 김진석2, 한상섭1
The biliary excretion kinetics of the active folate derivatives were examined after an intravenous injection of methotrexate at doses of 0.3 and 10mg/kg to clarify the mechanism of the acute decrease in the plasma folate by the dihydrofolate reductase inhibitors. Even at a higher dose than used in the clinical therapy, methotrexate did not cause any acute depletion of folate denvatives in the excreted bile. Therefore, the decrease in the plasma folate appeared not to be related with the biliary excretion process of folates. A factor responsible for the plasma folate depletion by DHFR inhibitors may be due to the malabsorption of folate derivatives excreted into the small intestine.
Key Words: methotrexate, active folate derivatives, bihary excretion kinetics

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