| Effect of superoxide anion in the regulation of artrial natriuretic peptide (ANP) secretion |
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Chang-won Kang, Nam-soo Kim, Ho-il Lee |
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College of Veterinary Medicine, Chonbuk National University |
| 심방이뇨호르몬의 분비조절에 있어서 superoxide anion의 영향 |
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강창원, 김남수, 이호일 |
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전북대학교 수의과대학 |
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| Abstract |
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Atrial Natriuretic Peptide(ANP) is a hormone with potent natriuretic, diuretic and relaxing properties of vascular smooth muscle. Specific chemical modulator responsible for the ANP secretion has not yet been found. Although atrial stretch of stretch-release is to be a major stimulus for the secretion of ANP, the precise mechano-molecular transduction mechanism responsible for its evoked secretion remains to be elucidated. It is interested to clarify the effect of superoxide anion in the stretch-induced ANP secretion. In order to investigate the effectg of $H_2O_2$ in the regulation of ANP secretion, a perfused model of left atrium of rats was used. The results obtained were as follows; 1. The ANP secretion and the extracellular fluid(ECF) translocation were accentuated by the effect of repetitive atrial distension-reduction volume at atrial pressure($4cmH_2O$). 2. The dilution curve showed to be in parallel between pure atriopeptin III (AP III) and perfusated buffer. 3. $H_2O_2(5{ imes}10^{-4}M)$ accenturated a strectch-release induced increase of the ANP secretion. The amount of released ANP was significantly(p<0.01) increased. These results suggest that the superoxide anion may be involved in the regulatory mechanism of mechanically activated ANP release. |
| Key Words:
ANP, superoxide anion, atrium, ECF |
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