Necrotizing meningoencephalitis in a pug dog in Korea

Bak, Eun-jung; Kim, Dae-yong; Kim, Jae-hoon; Kweon, Oh-hyeong

Korean Journal of Veterinary Research 1996;36(2):441-445.

Eun-jung Bak¹, Dae-yong Kim¹, Jae-hoon Kim², Oh-hyeong Kweon¹

¹College of Veterinary Mdeicine, Seoul National University
²National Veterinary Research Institute

Pug dog에서 발생한 괴사성 뇌막뇌염 증례보고

박은정¹, 김대용¹, 김재훈², 권오경¹

¹서울대학교 수의과대학
²수의과학연구소

Abstract

A case of necrotizing meningoencephalitis was described in a 3-year-old female pug dog. Significant histopathological changes were confined to the brain. Histopathologically, brain lesion of the pug dog was characterized by (1) severe lymphocyte, plasma cell and macrophage infiltration in the meninges and gray and white matter of the cerebral hemisphere, (2) perivascular mononuclear cell cuffing and (3) focal polioencephalomalacia in the gray matter of cerebrum. Replicate sections of the brain and lung were negative for fungal infection, canine distemper and toxoplasmosis on PAS stain and immunohistochemistry, respectively. Based on clinical signs, histopathological and immunohistochemical studies, this case was diagnosed as necrotizing meningoencephalitis in pug dog that had not been preriously described in Korea.

Key Words: Pug dog, necrotizing meningoencephalitis, encephalomalacia, cerebrum