Effect of lead on mitochondrial activity in rat tussues

Cho, Jong-hoo; Kwon, Oh-deog; Lee, Joo-mook

Korean Journal of Veterinary Research 1996;36(3):565-570.

Jong-hoo Cho, Oh-deog Kwon, Joo-mook Lee

College of Veterinary Medicine, Chonbuk National University

랫드의 조직 mitochondria 활성에 대한 납 투여의 영향

조종후, 권오덕, 이주묵

전북대학교 수의과대학

Abstract

Cardiac, hepatic and renal mitochondria in rats fed lead containing diets were isolated and their activities were studied in terms of NADH oxidation. In normal rats, cardiac and renal mitochondria had similar activities and showed activity values of higher than those in hepatic mitochondria. Cardiac mitochondiral activities in rats fed lead containing diets were increased after 4 weeks of feeding but decreased to activity values close to normal. Renal mitochondrial activities showed a trend of inhibition in all groups fed lead containing diets but were no differenes by feeding periods of 4 and 8 weeks. Feeding of lead containing diets could not be attributed to any changes in the hepatic mitochondrial antivities at experimental doses during 4~8 weeks.

Key Words: Lead acetate, lead containing diets, mitochondiral activity