Effect of cadmium on immune responses and enzyme activities in BALB/c mouse 2. Humoral immune responses |
Chang-yong Yoon, Jeong-gon Cho, Hee-jong Song |
College of Veterinary Mdicine & Bio-Safety Research Institute, Chonbuk National University |
카드뮴이 BALB/c 마우스의 면역반응 및 효소활성에 미치는 영향 2. 체액성 면역반응 |
윤창용, 조정곤, 송희종 |
전북대학교 수의과대학.생체안전성연구소 |
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Abstract |
This study was designed to investigated the effects of cadmium(Cd) feeding on the humoral immune responses such as PFC-responses and production of immunoglobulins in BALB/c mice. The results obtained were summarized as follows; 1. Total PFCs of direct IgM antibody response were significantly decreased in all Cd-fed goups, whereas total PFCs of IgG antibody response were slightly increased. 2. In secondary immunization, total HA titers were increased in all Cd groups as compared with control, especially in 100ppmm group and also IgG titers were slightly increased except for 50ppm group. 3. The levels of $IgG_1$ were increased to 5.5% 18.7%, 17.4% and 7.2% in 25, 50, 100 and 200ppm groups as compared with control, respectively. And also the levels of IgE were increased to 5.7%, 7.3%, 8.7% and 0.4% in those of Cd groups, in order. Conclusively, concentrations of $IgG_1$, and IgE were increased in all Cd groups. Based on the results of this study and previous report, it was shown that Cd might affect humoral immune responses by modifying the distribution and function of cells playing in the cellular immune response. |
Key Words:
cadmium, humoral immune respones, BALB/c mouse |
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